INHIBITING INTERACTION BETWEEN HIF-1alfa AND P300/CBP WITH HYDROGEN BOND SURROGATE-BASED HELICES

摘要

The present invention relates to peptidomimetics that mimic helix B of the C-terminal transactivation domain of HIF-1. Methods of using the peptidomimetics to, e.g., inhibit the HIF-1-p300/CBP interaction, are also disclosed.