SYNTHESIS OF AN INJECTABLE MULTIPHASIC GEL CONTAINING FREE AND CROSS-LINKED MONOPHASIC HYALURONIC ACID AND BIPHASIC HYALURONIC ACID COMBINED WITH HYDROXYAPATITE WITH MICROENCAPSULATED HYALURONIDASE INHIBITOR.

摘要

The present invention relates to the field of the cosmetic medicine and, more specifically, the injection products to be used for filling wrinkles and restoring volume to the face and body or as a bone tissue substitute, and it concerns a synthesis of an injectable multiphasic gel containing cross-linked monophasic hyaluronic acid, biphasic hyaluronic acid combined with hydroxyapatite and a microencapsulated hyaluronidase inhibitor that offers better tissue filling ability due to combination of biphasic hyaluronic acid with hydroxyapatite, its better distribution and adhesion in the tissues due to the presence of free and cross-linked monophasic hyaluronic acid and its longer time in situ due to the presence of a microencapsulated hyaluronidase inhibitor.