METHOD OF DETECTION AND QUANTIFICATION BY MASS SPECTROMETRY AND BY ACTIVATING IONISED MOLECULAR SPECIES

摘要

Disclosed is a system and method of mass spectrometry, including: a. ionizing an analyte to form a precursor ion (A) having a mass-to-charge ratio (m/z), in which m represents the mass and z the electric charge number; b. activating the precursor ion (A) by interaction with a beam of neutral species, ions, electrons or photons, having an energy chosen on the basis of the physicochemical properties of the precursor ion, the activation being suitable for producing a product ion (B, C) having the same mass m as the precursor ion (A) and an electric charge number z′ such that z′ is a non-zero integer different from z; c. separating the product ion (B, C, E, F) having a predefined mass-to-charge ratio (m/z′); d. detecting the product ion (B, C) having the predefined mass-to-charge ratio (m/z′).