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METHODS OF RECOMBINANT PROTEIN EXPRESSION IN A CELL COMPRISING REDUCED UDP-GALACTOSE TRANSPORTER ACTIVITY
METHODS OF RECOMBINANT PROTEIN EXPRESSION IN A CELL COMPRISING REDUCED UDP-GALACTOSE TRANSPORTER ACTIVITY
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机译:包含降低的UDP-半乳糖转运蛋白活性的细胞中重组蛋白表达的方法
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摘要
We describe a method of reducing batch-to-batch variation or increasing homogeneity between batches in the production of a recombinantly expressed polypeptide. The method comprises expressing the polypeptide in a Chinese hamster ovary (CHO) cell comprising reduced UDP-galactose transporter activity compared to a wild-type CHO cell. In some embodiments, the CHO cell further comprises reduced GDP-fucose transporter activity.
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