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COMBINATION THERAPY OF INHIBITORS OF C-C CHEMOKINE RECEPTOR TYPE 9 (CCR9) AND ANTI-ALHA4BETA7 INTEGRIN BLOCKING ANTIBODIES
COMBINATION THERAPY OF INHIBITORS OF C-C CHEMOKINE RECEPTOR TYPE 9 (CCR9) AND ANTI-ALHA4BETA7 INTEGRIN BLOCKING ANTIBODIES
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机译:C-C型9型趋化因子受体抑制剂(CCR9)和抗ALHA4BETA7整合素阻滞剂的联合治疗
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摘要
Provided herein are compositions, methods and kits for treating inflammatory bowel disease (IBD) such as Crohn's disease and ulcerative colitis in a mammal in need thereof. The method include administering to a subject with IBD a combination therapy containing a therapeutically effective amount of a chemokine receptor 9 (CCR9) inhibitor compound and a therapeutically effective amount of an anti-α4β7 integrin antibody such as vedolizumab. Also provided herein is a kit containing the CCR9 inhibitor compound and anti-α4β7 integrin antibody.
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