首页> 外国专利> PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE BY GENOME EDITING USING THE CRISPR/CAS SYSTEM

PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASE BY GENOME EDITING USING THE CRISPR/CAS SYSTEM

机译：使用CRISPR / CAS系统进行基因组编辑来预防和治疗老年痴呆症

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摘要

Methods and products are described related to use of the CRISPR/Cas9 system to introduce a modification into an APP gene, such as guide RNAs and recombinant proteins, for decreasing amyloid beta peptide produced by a cell. Also described are uses of such methods and products for the treatment of Alzheimer's disease and/or age-related cognitive decline in a cell from a subject in need thereof.

机译：描述了与使用CRISPR / Cas9系统将修饰引入APP基因（例如，指导RNA和重组蛋白）以减少细胞产生的淀粉样β肽有关的方法和产品。还描述了此类方法和产品在治疗阿尔茨海默氏病和/或有需要的受试者的细胞中与年龄相关的认知下降中的用途。

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公开/公告号EP3140403A1

专利类型
公开/公告日2017-03-15

原文格式PDF
申请/专利权人 UNIVERSITÉ LAVAL;
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申请/专利号EP20150789631
发明设计人 TREMBLAY JACQUES P.;ROUSSEAU JOËL;CHAPDELAINE PIERRE;
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申请日2015-05-08
分类号C12N15/63;A61K48;A61P25/28;C12N15/09;C12N15/113;C12N15/12;C12N15/55;C12N15/85;C12N15/86;C12N15/90;
国家 EP
入库时间 2022-08-21 14:04:09

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