MEANS AND METHODS FOR IDENTIFYING A PATIENT HAVING A BRAF-POSITIVE CANCER AS A NON-RESPONDER TO A BRAF INHIBITOR AND AS A RESPONDER TO AN MAPK/ERK INHIBITOR

摘要

The present invention relates to the field of diagnostics, in particular, cancer diagnostics. More specifically, it relates to a method for identifying whether a subject suffering from a BRAF-positive cancer is a non-responder to a BRAF inhibitor, or not, and/or is a responder to an MAPK/ERK inhibitor, a method for diagnosing cancer, a method for assessing responsiveness to targeted therapy in a subject and a method for assessing cancer in a subject. Moreover, contemplated by the invention are a kit and a device for diagnosing cancer. Further, the invention relates to a MAPK/ERK inhibitor for use in treating a subject suffering from a BRAF-positive cancer.