THIOETHER COMPOUND FOR THE PROTECTION OF THE 2'-HYDROXY GROUP IN NUCLEOSIDES TO BE USED IN OLIGONUCLEOTIDE SYNTHESIS.

摘要

An ether is provided which may be used in the production of a glycoside, and method of producing the ether. The ether is represented by the following chemical formula (106):in said chemical formula (106),R⁴ is a hydrocarbon group, a straight chain or branched alkyl group, a straight chain or branched alkenyl group, a straight chain or branched alkynyl group, an aryl group, a straight chain or branched arylalkyl group, a cycloalkyl group, a cycloalkenyl group, a straight chain or branched cycloalkylalkyl group, a straight chain or branched cyclylalkyl group, or a straight chain or branched alkoxyalkyl group,n is a positive integer,L¹ is an ethylene group (-CH₂CH₂-), wherein hydrogen atoms besides a hydrogen atom bonded to the α-position relative to [D¹] are optionally substituted by a straight chain or branched alkyl group, and[D¹] is an electron-withdrawing group.