miRNA USEFUL TO REDUCE LUNG CANCER TUMORIGENESIS AND CHEMOTHERAPY RESISTANCE AND RELATED COMPOSITION AND METHOD

摘要

PROBLEM TO BE SOLVED: To provide compositions, such as nucleic acids, vectors, cells, and animal models, useful to reduce tumor growth, cancer cell migration, and various other cancer pathologies associated with EGFR (epidermal growth factor receptor) and MET (the receptor tyrosine kinase for hepatocyte growth factors) dysregulation in non-small cell lung carcinoma accounting for approximately 85% of all cases of lung cancer.SOLUTION: The pharmaceutical composition for inhibiting tumor growth in a mammal comprises an anti-miR-30 gene product. The anti-miR-30 gene product includes isolated nucleotides 288-294 (5'-TGTTTACA-3') of the miR-30b binding site of BIM. In the pharmaceutical composition, the anti-miR-30 gene product is used in combination with a chemotherapeutic treatment for lung cancer.SELECTED DRAWING: None