HYPROMELLOSE ACETATE SUCCINATE POWDERS HAVING EXCELLENT CLARITY AND COLOR OF SOLUTION AND PRODUCTION METHOD THEREOF, AS WELL AS EACH PRODUCTION METHOD OF SOLID DISPERSION COMPOSITION, COATING COMPOSITION, DRUG-CONTAINING PARTICLES, AND SOLID PREPARATIONS

摘要

PROBLEM TO BE SOLVED: To provide HPMCAS powders having high solubility at the time of dissolving in a solvent and capable of suppressing generation of undissolved materials, and to provide production methods thereof.;SOLUTION: Provided is a hypromellose acetate succinate powder having the mean value of the ratio (L/D) of a maximum diameter (L) and a minimum diameter (D) of 2.0 to 3.0. Also provided is a production method of hypromellose acetate succinate at least comprising a dissolution step of dissolving hypromellose in a solvent, an esterification step of reacting succinic anhydride and acetic anhydride to the dissolved hypromellose in the presence of a catalyst to obtain a reaction solution, and a precipitation step of precipitating hypromellose acetate succinate by mixing the reaction solution and water, wherein the viscosity of the reaction solution before mixing with water is 100 to 200 Pa s.;SELECTED DRAWING: None;COPYRIGHT: (C)2018,JPO&INPIT