HYPROMELLOSE ACETATE SUCCINATE POWDER EXCELLENT IN DISSOLVED STATE AND PRODUCTION METHOD THEREOF, AND PRODUCTION METHODS FOR COMPOSITION FOR SOLID DISPERSION, COATING COMPOSITION, DRUG-CONTAINING PARTICLE, AND SOLID PREPARATION

摘要

[Problem] To provide an HPMCAS powder having high solubility when dissolved in a solvent and capable of suppressing the generation of undissolved substances, and a method for producing the same. [Solutions] To provide a hypromellose acetate succinate powder having an average value of the ratio (L/D) of the maximum diameter (L) and the minimum diameter (D) of 2.0 to 3.0. In addition, a dissolution step of dissolving hypromellose in a solvent, an esterification step of obtaining a reaction solution by reacting succinic anhydride and acetic anhydride with the dissolved hypromellose in the presence of a catalyst, and the reaction solution and water It is a precipitation step of precipitating hypromellose acetate succinate ester by mixing, and at least comprising a precipitation step in which the viscosity of the reaction solution before mixing with water is 100 to 200 Pa·s. A manufacturing method is provided.