TREATING BASAL CELL-LIKE GENOTYPE CANCERS

摘要

PROBLEM TO BE SOLVED: To provide methods of treating a subject with cancer comprising administering a death receptor agonist to the subject.SOLUTION: Also provided herein are methods of screening a breast cancer cell for responsiveness to a DR5 agonist. Further provided herein are antibodies that selectively bind an N-terminal CARD of DDX3, a DDX3 lacking an N-terminal CARD, and an 80 kDa baculovirus IAP repeat (BIR). The methods comprise detecting in the breast cancer cell IAP proteins including an 80 kDa baculovirus IAP repeat.SELECTED DRAWING: None