SYSTEMS AND METHODS FOR NETWORK-BASED BIOLOGICAL ACTIVITY ASSESSMENT

摘要

PROBLEM TO BE SOLVED: To provide systems and methods for network-based biological activity assessment.SOLUTION: Systems and methods are provided for quantifying perturbation of a biological system in response to an agent. Treatment and control data are received at a processor and used to calculate activity measures for nodes of a computational causal network model of biological entities in a biological system. A perturbation score is generated for the model, characterizing the effect of the treatment agent on the biological system. In one aspect, the systems and methods described herein are directed to computerized methods and one or more computer processors for quantifying the perturbation of a biological system in response to an agent.SELECTED DRAWING: Figure 6