METHODS FOR DETERMINING CANCER RESPONSIVENESS TO TREATMENTS TARGETING EPITHELIAL CELL GROWTH FACTOR RECEPTOR

摘要

PROBLEM TO BE SOLVED: To provide novel methods for determining the likelihood of effectiveness of an epithelial cell growth factor (EGFR) targeting treatment in a human patient affected with cancer, as well as treating methods.;SOLUTION: The invention is directed to a method for determining the responsiveness of cancer to an epithelial cell growth factor receptor (EGFR) treatment. In preferred aspects, as the presence of at least one variance in the kinase domain of the erbB 1 gene gives sensitivity to a tyrosine kinase inhibitor gefitinib, a diagnostic assay for these variances enables administration of gefitinib, erlotinib and other tyrosine kinase inhibitors to those patients most likely to respond to the drug.;SELECTED DRAWING: Figure 1;COPYRIGHT: (C)2017,JPO&INPIT