ADJUVANT FOR MUCOSAL VACCINE TO ACTIVATE INNATE IMMUNITY

摘要

PROBLEM TO BE SOLVED: To provide an effective and safe adjuvant substance for a mucosal vaccine to be used for a transmucosal administration-type vaccine.SOLUTION: An adjuvant for a mucosal vaccine consists of a substance that enhances production of a natural antibody or a substance that activates innate immunity. The substance is selected from a group consisting of a substance that enhances natural antibody production of B cells, a substance that enhances IL-5 production, a substance that activates dendritic cells, a substance that activates inflammasomes, and a substance that enhances IFN-γ production. A vaccine composition to be transmucosally administered comprises an inactivated antigen derived from a virus or pathogen and at least one adjuvant for the mucosal vaccine.SELECTED DRAWING: None