HIV vaccine comprising one or more types of population epicensus antigens

摘要

Provided herein is an HIV-1 vaccine comprising a carrier and a population epicensus antigen determined using an EpiGraph approach. An HIV-1 vaccine comprising a carrier, a population epicensus antigen and a tailored antigen is also provided. Designing vaccine antigens to optimally cover diversity within a geographic region using antigen amino acid sequences generated using the EpiGraph approach, and producing designed vaccine antigens It also provides a way to design and produce an HIV-1 vaccine. An effector memory T cell comprising the steps of designing one or more types of EpiGraph amino acid sequences, producing a vaccine comprising the one or more types of EpiGraph amino acid sequences and a vector, and administering the vaccine to a subject. A method of inducing a response is also provided. Further provided is a method of treating HIV-1 in a subject comprising administering to the subject in need thereof an effective amount of the HIV-1 vaccine described above.