Transdermal in vivo measurement method and apparatus by Raman spectroscopy

摘要

The use of transcutaneous Raman spectra to measure glucose or other substance concentrations can give inaccurate results if the Raman signal occurs at the wrong skin depth. Of a Raman signal having at least one component received percutaneously at the confocal detection device and expected to have an intensity representative of the concentration of glucose or another skin component at the point of origin of the Raman signal below the surface of the skin In order to predict whether the spectrum accurately represents the concentration, spectral peaks at 883/4 cm −1 and 894 cm −1 were measured, and a Raman signal occurred mainly in the stratum corneum, so the spectrum was Is less likely to be accurately represented or occurs mainly below the stratum corneum, and thus the spectrum is likely to accurately represent the concentration.