ROLE OF N-2 HYDROXY-ETHYL-PIPERAZINE-N'-2-ETHANE SULFONIC ACID (HEPES) IN PAIN CONTROL AND REVERSAL OF DEMYELINATION INJURY

摘要

PROBLEM TO BE SOLVED: To provide pharmaceutical compositions for treating one or more neurodegenerative diseases accompanied by demyelination.SOLUTION: The invention relates to a composition containing N-2 hydroxy-ethyl-piperazine-N'-2-ethane sulfonic acid (HEPES) and derivatives in the treatment of pain associated with cancers and side-effects including post-chemotherapy cognitive impairment disclosed herein, and to a therapeutic use of the composition. HEPES is also used to treat neurodegenerative and neurological diseases, demyelination injuries, and side-effects and withdrawal symptoms associated with benzodiazepines, anti-depressants, and other neurological agents.SELECTED DRAWING: None