Peptide dendrimers containing fibrinogen binding peptides

摘要

Peptide dendrimers and agents that can be used to polymerize fibrinogen and as a hemostatic agent are described. Peptide dendrimers include a branched core and a plurality of fibrinogen binding peptides that are individually covalently bonded to the branched core. The branched core is i) 2 to 10 multifunctional amino acid residues, wherein each fibrinogen binding peptide is individually covalently linked to a multifunctional amino acid residue of the branched core; ii) one or more fibrinogen bonds A plurality of multifunctional amino acid residues, wherein the peptide is individually covalently linked to each of at least two adjacent multifunctional amino acid residues of the branched core; iii) two or more fibrinogen binding peptides of the branched core A plurality of multifunctional amino acid residues individually covalently linked to at least one multifunctional amino acid residue; iv) two or more multifunctional amino acid residues are adjacent polyfunctional amino acid residues A plurality of multifunctional amino acid residues covalently linked through the side chain of: or v) one multifunctional amino acid residue, and the fibrinogen binding peptide is a multifunctional amino acid Covalently attached individually to each functional group of the residue. The plurality of multifunctional amino acid residues includes trifunctional or tetrafunctional amino acid residues, or trifunctional and tetrafunctional amino acid residues, or one multifunctional amino acid residue is trifunctional Or tetrafunctional amino acid residues. [Selection] Figure 6