Therapeutic drug delivery device having an advanceable cannula and needle

摘要

An apparatus (410) for delivering a therapeutic agent to the eye comprises a body (440), a cannula (420), a hollow needle (430), a cannula actuation assembly (500), and a needle actuation assembly (550). Prepare. The cannula is sized and configured to extend distally from the body and be insertable between the choroid and sclera of the patient's eye. The cannula actuation assembly is operable to actuate the cannula relative to the body. The needle actuation assembly is operable to actuate the needle relative to the cannula. The cannula is inserted through a scleral incision to position the distal end of the cannula between the choroid and sclera in the posterior region of the eye. The needle can be advanced through the choroid and deliver a therapeutic agent adjacent to the potential gap between the neurosensory retina and the retinal pigment epithelial layer adjacent to the area of maple atrophy.