Methods for the treatment, diagnosis and prognosis of hematological malignancies

摘要

The present invention relates to a serotonin receptor (5-HTR) selected from the group consisting of type 1 5-HTR inhibitors and type 2 5-HTR inhibitors for use in the prevention and / or treatment of hematological malignancies. Relates to inhibitors. Furthermore, the present invention relates to hematological malignancies for identifying or isolating malignant cells derived from hematological malignancies or based on detection of expression of type 1 5-HTR and / or type 2 5-HTR. It relates to in vitro methods for diagnosis. Furthermore, the present invention relates to determining the prognosis based on the determination of the level of type 1-HTR and / or type 2 5-HTR, for monitoring the effect of a therapy, or It relates to in vitro methods for designing customized therapies in affected subjects. [Selection figure] None