Covalently linked diabody having immunoreactivity with PD-1 and LAG-3 and method of use thereof

摘要

The invention comprises at least one epitope binding site comprising two or more polypeptide chains and immunospecific for an epitope of PD-1 and at least one immunospecific for an epitope of LAG-3 A bispecific diabody having an epitope binding site (ie, “PD-1 × LAG-3 bispecific diabody”) is targeted. More preferably, the present invention comprises two epitope binding sites comprising four polypeptide chains and immunospecific for one (or two) epitopes of PD-1 and one of LAG-3 ( Or a bispecific diabody (ie, “PD-1 × LAG-3 bispecific tetravalent diabody”) with two epitope binding sites that are immunospecific for two epitopes . [Selection] Figure 4