Molecular diagnostic tests for response to anti-angiogenic drugs and prediction of cancer prognosis

摘要

A method for selecting whether to administer an anti-angiogenic therapeutic agent to a subject comprises measuring the expression level of one or more biomarkers selected from Table 2 or Table 3 in a sample derived from the subject; 1 An anti-angiogenic treatment if the sample is positive for the biomarker signature, comprising evaluating from a level of expression of the one or more biomarkers whether the sample from the subject is positive or negative for the biomarker signature The drug is contraindicated. Related prognostic methods and treatment methods are also provided. The present invention is particularly applicable to ovarian cancer and colorectal cancer.