Compositions and methods for treating diseases using Salmonella T3SS effector protein (SipA)

摘要

The present invention provides compositions and methods that reduce one or more symptoms of a disease by administering a composition comprising SipA. The compositions and methods of the present invention are particularly beneficial in reducing the symptoms of diseases associated with overexpression of P-gp and / or p53. The compositions and methods of the present invention are useful in reducing cancer symptoms and / or cancer multidrug resistance (MDR). The present invention provides a method of reducing one or more symptoms of cancer in a mammalian subject in need thereof, comprising administering to said subject a composition comprising purified SipA. In one embodiment, the SiPA is functionally bound to the nanoparticles. In another embodiment, the cancer comprises cancer cells that are resistant to at least one cytotoxin. [Selection] Figure 1