Substituted 2-thioxo-imidazolidin-4-one and spiro analogs thereof, anticancer active ingredients, pharmaceutical compositions, pharmaceutical formulations, and methods of treating prostate cancer

摘要

The present invention relates to novel (R) -stereoisomers of substituted 2-thioxo-imidazolidin-4-ones of formula 1 that exhibit the properties of androgen receptor antagonists, or spiro analogs thereof, and derivatives of the process Relates to intermediate compounds for the production of compounds of the type and formula 1. The compound of formula 1 can be used to produce a medicament suitable for the treatment of cancers such as prostate cancer and breast cancer. The invention further relates to pharmaceutical compositions in the form of tablets, capsules and injections. In Formula 1, R1 is OH, NH2, or OR4, R2 and R3 are methyl groups, or R2 and R3 are CH2-CH2, and R4 is С1-С4 alkyl or cyclopropyl. [Chemical 1]