Methods of treating red blood cell production by increasing red blood cell levels by inhibiting activin B and / or GDF11

摘要

In certain aspects, the present disclosure provides compositions and methods for increasing red blood cells and / or increasing hemoglobin levels in a subject in need of increasing red blood cells and / or increasing hemoglobin levels. To do. Subjects in need thereof include, for example, subjects with anemia and subjects with ineffective erythropoiesis disorders. In certain aspects, the disclosure provides a method for increasing red blood cell levels, treating or preventing anemia, and / or treating or preventing ineffective erythropoiesis in a subject comprising increasing red blood cell levels and anemia. An effective amount of an agent or combination of agents that antagonizes (or inhibits) at least activin B and / or GDF11 in a subject in need of treatment or prevention and / or treatment or prevention of ineffective erythropoiesis A method is provided comprising the step of administering.