Application of cyclic dinucleotide cGAMP in antitumor

摘要

The present invention relates to the field of medical technology, and in particular to the application of the cyclic dinucleotide cGAMP in treating tumors. According to the research of the present invention, cGAMP can suppress the growth of various tumor cells, and can be used for the production of antitumor drugs due to its remarkable antitumor activity. Tumor drugs are effective with low toxicity. According to the nude mouse subcutaneous transplantation tumor model, cGAMP is human gastric cancer cell line MNK-45, human lung adenocarcinoma cell line A549, human colon cancer cell line Lovo, human liver cancer cell line SMMC-7721, human prostate cancer The cell line PC-3 and human pancreatic cancer cell SW1990 nude tumors transplanted in nude mice all have a significant inhibitory effect, and according to the animal acute toxicity test, the acute toxicity of cGAMP is relatively low. Can be used in the manufacture of medicines.