O-acetylated polymeric polygalacturonic acid and its use as a Vi polysaccharide vaccine

摘要

The disclosure provides (a) a molecular weight greater than 1 × 10 6 Da; (b) a degree of methylation of less than about 10% per mole; and (c) an intervening rhamnose content ranging from about 2% to about 15% per mole An O-acetylated polymeric polygalacturonic acid or a pharmaceutically acceptable salt thereof useful as a synthetic immunogenic Vi antigen having at least one of: The present disclosure further provides methods of producing O-acetylated polymeric polygalacturonic acid or pharmaceutically acceptable salts thereof, pharmaceutical compositions and / or vaccine compositions containing them, and immunization using any of the foregoing. Provide a way to