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O-acetylated high molecular weight polygalacturonic acids and their use as Vi polysaccharide vaccine
O-acetylated high molecular weight polygalacturonic acids and their use as Vi polysaccharide vaccine
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机译:O-乙酰化高分子量聚半乳糖醛酸及其作为Vi多糖疫苗的用途
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摘要
The instant disclosure provides O-acetylated high molecular weight polygalacturonic acids or pharmaceutically acceptable salts thereof, having at least one of: (a) a molecular weight greater than 1 x 106 Da; (b) a degree of mefhylation less than about 10% per mole; and (c) an intervening rhamnose content ranging from about 2% to about 15% per mole, useful as a synthetic immunogenic Vi antigen. The instant disclosure further provides methods of preparing an O-acetylated high molecular weight polygalacturonic acid or pharmaceutically acceptable salt thereof of, pharmaceutical compositions and/or vaccine compositions comprising the same, and methods of immunization using any of the foregoing.
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