2- (R2-thio) -10- 3- (4-R1-piperazin-1-yl) propyl -10H-phenothiazine and β-amyloid pathy for the treatment of β-amyloidopathy or α-synucleopathy Method for diagnosis or pre-diagnosis of α-synucleopathy

摘要

Use of substituted 10-(3-piperazin-1-yl-propyl)-10H-phenothiazine-2-thiol compounds (I) for treating neurodegenerative diseases, is claimed. Use of substituted 10-(3-piperazin-1-yl-propyl)-10H-phenothiazine-2-thiol compounds of formula (I) for treating neurodegenerative diseases, is claimed. R1, R2 : 1-6C-alkyl (optionally substituted by alkyl (optionally substituted by at least one further halo atom), aryl, acyl, acetyl, amino, nitro, sulfonyl, hydroxyl, alkoxy, aryloxy, arylthio, alkylthio or halo); R3 : H, alkyl (optionally substituted by at least one further halo atom), aryl, acyl, acetyl, amino, nitro, sulfonyl, hydroxyl, alkoxy, aryloxy, arylthio, alkylthio, halo, NR4R5- or OR6; R4-R6 : H or 1-3C-alkyl; R7 : H, alkyl (optionally substituted by at least one further halo atom), aryl, acyl, acetyl, amino, nitro, sulfonyl, hydroxyl, alkoxy, aryloxy, arylthio, alkylthio, halo, NR8R9 or OR10; and R8-R10 : H or 1-3C-alkyl. [Image] ACTIVITY : Neuroprotective; Nootropic; Anticonvulsant; Antiparkinsonian; Cerebroprotective; Hypnotic; Antiinflammatory. MECHANISM OF ACTION : None given.