Methods and compositions for treating heart failure with preserved left ventricular ejection fraction

摘要

A pharmaceutical composition for treating a person suffering from heart failure (HFPEF), diastolic heart failure (DHF) or diastolic dysfunction (DF) in which left ventricular ejection fraction is maintained, comprising fibroblasts in the myocardium, Specifically bind to relaxin receptor (RXFP1) present on myofibroblasts, endothelial cells, endocardial cells and cardiomyocytes to increase cardiac stroke volume at lower end-diastolic pressure A pharmaceutical composition comprising a therapeutically effective amount of a compound capable of