P38 and JNK MAPK inhibitors for treating and preventing degenerative diseases of the nervous system

摘要

The present invention provides novel p38 and JNK mitogen activated protein (MAP) kinase allosteric inhibitors useful for the treatment and / or prevention of degenerative diseases of the nervous system. Accordingly, the present invention provides compounds used in methods for the treatment and / or prevention of the diseases as well as compounds used in general therapy. The compound comprises MAP kinase 14 (Uniprot accession number Q16539 or SEQ ID NO: 1) and / or MAP kinase 11 (Uniprot accession number Q15759 or SEQ ID NO: 2), that is, amino acids of MAPK14 (p38α) and MAPK11 (p38β), respectively. It binds to a region composed of amino acids at positions 170 to 199 of SEQ ID NOs: 1 and 2, which are sequences. Specific regions composed of amino acids 170-199 are disclosed as SEQ ID NO: 4 for MAP kinase 14 and SEQ ID NO: 5 for MAP kinase 11, which are considered novel inhibitory binding sites.