Optimized early-late promoter combined with repeated vaccination favors cytotoxic T cell responses to antigens in replication-deficient recombinant virus vaccines

摘要

The present invention relates to a replication deficient recombinant virus encoding at least one antigen and/or antigenic epitope, wherein expression of said antigen and/or antigenic epitope is regulated by a transcriptional control element comprising at least two elements driving early expression of said antigen and/or antigenic epitope and the use of said replication deficient recombinant virus as medicament or vaccine.