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Novel steroid 11β-hydroxylase and method for producing 11β-hydroxysteroid using the same

机译:新型类固醇11β-羟化酶及使用该酶生产11β-羟类固醇的方法

摘要

PROBLEM TO BE SOLVED: To provide a new steroid 11-hydroxylase useful for producing a 11-hydroxysteroid such as a hydrocortisone.SOLUTION: There is provided a protein of (a1), (b1) or (c1): (a1) a protein including a specific amino acid sequence, (b1) a protein including an amino acid sequence in which one or some amino acids are deleted, substituted or added in a specific amino acid sequence, and having steroid 11-hydroxylation activity, (c1) a protein including an amino acid sequence with a sequence identity of not less than 90% to a specific amino acid sequence, and having steroid 11-hydroxylation activity.
机译:解决的问题:提供一种新的甾体11-羟化酶,可用于生产11-羟类固醇,例如氢化可的松。解决方案:提供了一种(a1),(b1)或(c1)的蛋白质:(a1)一种蛋白质(b1)蛋白质,该蛋白质包括在特定氨基酸序列中缺失,取代或添加一个或多个氨基酸的氨基酸序列,并且具有类固醇11-羟基化活性,(c1)蛋白质包括与特定氨基酸序列具有不少于90%的序列同一性并且具有甾族11-羟基化活性的氨基酸序列。

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