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Data acquisition method for ATLL diagnosis, ATLL diagnosis kit and ATLL diagnosis system
Data acquisition method for ATLL diagnosis, ATLL diagnosis kit and ATLL diagnosis system
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机译:用于ATLL诊断的数据获取方法,atll诊断套件和atll诊断系统
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摘要
PROBLEM TO BE SOLVED: To provide a means for being capable of carrying out early, highly sensitive and highly accurate diagnosis of ATLL (adult T-cell leukemia/lymphoma), especially highly malignant (acute or lymphoma type) ATLL.SOLUTION: There is provided a data acquisition method for ATLL diagnosis characterized by including a step of assaying the expression amount in a sample about at least one kind of miRNA selected from the group consisting of miRNA and its variant the ratio of which is ≥2 times or ≤0.5 times the ratio of a standard of the expression amount in CD4-positive T-cells collected from a smoldering type or chronic type ATLL patient or the like, a CD4-positive T-cell culture or the like collected from lymphoma type ATLL patients, or a CD4-positive T-cell culture derived from ATLL non-tumorous cells, based on the expression amount in peripheral blood from healthy subjects, peripheral blood mononuclear or activated CD4-positive T-cell (hereinafter, designated as "(activated) CD4-positive T-cells or the like"), a CD4-positive T-cell or the like originated from an HTLV-I (human T cell leukemia virus I type) carrier, a CD4-positive T-cell or the like derived from a smoldering type or chronic type ATLL patient, or a HTLV-I infected and immortalized CD4-positive T-cell culture or a CD4-positive T-cell culture derived from ATLL non-tumorous cells.
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