Method for predicting therapeutic effect on colorectal cancer patients with enhanced expression of TK1 protein

摘要

The present invention provides the therapeutic effect of chemotherapy using an antitumor agent containing trifluridine and tipiracil hydrochloride in a molar ratio of 1: 0.5 in colorectal cancer patients, comprising the following steps (1) to (3): Provide a way to predict. As means for solving such problems, the following inventions are provided: (1) a step of detecting the expression of TK1 protein in the cytoplasm of tumor cells contained in a biological sample collected from the patient by immunohistochemistry ( 2) From the detection result obtained in the above step (1), classifying tumor cells into positive cells and negative cells, calculating the occupancy of positive cells in the tumor cells, and (3) in step (2) above From the obtained calculation results, when the occupation ratio is 30% or more, chemotherapy using an antitumor agent containing trifluridine and tipiracil hydrochloride in a molar ratio of 1: 0.5 is sufficient for the patient. A method comprising a step of predicting that the possibility of showing an effect is high.