Transgenic mouse expressing human TGFβ1 specifically in kidney and biomarker for tissue fibrosis mouse model

摘要

PROBLEM TO BE SOLVED: To provide a TG mouse that expresses TGFβ1 specifically in the kidney and spontaneously develops renal fibrosis. This is achieved by a transgenic mouse comprising the promoter region of mouse Podocin and the entire gene region of human transforming factor β1 (human TGFβ1) that is located downstream of the promoter region and whose expression is controlled. At this time, it is preferable that the transgenic mouse spontaneously develops renal fibrosis / renal failure from the age of 15 weeks of age and begins to die from 20 to 26 weeks of age. [Selection] Figure 5