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For multi-substituted 7-deazapurine derivatives synthesized 2,6-dichloro-8-iodo-7-deazapurine
For multi-substituted 7-deazapurine derivatives synthesized 2,6-dichloro-8-iodo-7-deazapurine
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机译:对于多取代的7-脱氮嘌呤衍生物,合成了2,6-二氯-8-碘-7-脱氮嘌呤
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摘要
PROBLEM TO BE SOLVED: To overcome many times and labors needed for synthesizing various polysubstituted 7-deazapurine derivatives which is expected usefulness or the like as pharmaceutical because they are conventionally synthesized through several synthetic routes depending on kinds and positions of substituents.;SOLUTION: Used is 2,6-dichloro-8-iodo-7-deazapurine represented by the following formula (1) available as a key intermediate of polysubstituted 7-deazapurine derivatives. Predetermined substituents can be introduced to 8-, m6- and 2-positions respectively in this order, therefor it is useful as an intermediate for synthesizing targeted polysubstituted 7-deazapurine derivative.;SELECTED DRAWING: None;COPYRIGHT: (C)2016,JPO&INPIT
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