;wherein X is selected from the group consisting of hydrogen, halogen, a cyano group, a trifluoromethyl (CF3) group, an amidine (C(═NH)NH2) group, and a 5-methyl-1,2,4-oxadiazole group, Y is selected from the group consisting of hydrogen, halogen, a phenyl group substituted with one or two substituents selected from the group consisting of halogen, methoxy, nitro, trifluoromethyl, and aminomethyl, CO—R′, COOR′, OH, O—R′, and NH—R′, each R′ is independently selected from the group consisting of C1-C18 alkyl, alkenyl, alkynyl, and —Z-alkyl (wherein Z is a heteroatom selected from the group consisting of O, S, and N or is —(CH2)m—), and m is an integer from 0 to 5. Also disclosed are methods for preparing the phenol derivatives and pharmaceutical compositions for inhibiting cell proliferation and migration including the phenol derivatives. The phenol derivatives and the pharmaceutical compositions can effectively inhibit the proliferation and migration of kinase-overexpressed cells and can be used for the prevention or treatment of various solid cancers and metastatic cancers."/>
公开/公告号US2017129879A1
专利类型
公开/公告日2017-05-11
原文格式PDF
申请/专利权人 KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION;DONGGUK UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION;
申请/专利号US201615295293
申请日2016-10-17
分类号C07D413/14;C07D209/14;C07D409/10;C07D209/12;C07D413/04;
国家 US
入库时间 2022-08-21 13:52:29