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METHOD, DEVICE, AND COMPUTER PROGRAM FOR ASSEMBLING PIECES OF CHROMOSOMES FROM ONE OR SEVERAL ORGANISMS

机译:用于组装来自一个或多个有机体的染色体片段的方法,装置和计算机程序

摘要

A method of assembling a sequence representing pieces of at least one chromosome from a set of raw sub-sequences representing DNA fragments of a library including DNA fragments including chains of contiguous nucleotides and including DNA fragments including combinations of at least two chains of contiguous nucleotides. After having obtained first values representing contact frequencies between DNA regions, the first values being associated with second values representing distances between the corresponding DNA regions, the method includes: updating a genome structure based on the first and second values and based on a theoretical model associating a contact probability between DNA regions with a distance between the corresponding DNA regions, the updated genome structure being representative of the real genome structure of the chromosome; and updating parameters of the theoretical model as a function of the updated genome structure.
机译:一种从代表库的DNA片段的一组原始亚序列中代表至少一个染色体片段的序列的方法,所述原始亚序列包括文库的DNA片段,所述DNA片段包括连续核苷酸的链,并且包括DNA片段,所述DNA片段包括至少两个连续核苷酸的链的组合。在获得表示DNA区域之间的接触频率的第一值,将第一值与表示相应DNA区域之间的距离的第二值相关联之后,该方法包括:基于第一和第二值以及基于理论模型,更新基因组结构DNA区域之间的接触概率与相应DNA区域之间的距离,更新的基因组结构代表染色体的真实基因组结构;以及根据更新的基因组结构更新理论模型的参数。

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