METHODS FOR PREDICTING RESPONSE TO DNA REPAIR PATHWAY INHIBITORS IN DIFFUSE LARGE B-CELL LYMPHOMA

摘要

The present invention relates to a method of testing whether a patient suffering from arge B-cell lymphoma will respond or not to a DNA repair pathway inhibitor comprising: i) determining the expression level (ELi) of several genes Gi-Gn selected from table A in a biological sample obtained from said patient comparing the expression level (ELi) determined at step i) with a predetermined reference level (ELRi) iii) calculating the DNA repair score trough the following formula (I), wherein βi represent the regression β coefficient reference value for the gene Gi and Ci=1 if the expression of the gene Gi (ELi) is higher than the predetermined reference level (ELRi) or Ci=−1 if the expression of the gene (ELi) is lower than or equal to the predetermined reference level (ELRi) iv) comparing the score DNARS determined at step iii) with a predetermined reference value DNARS_R v) and concluding that the patient will respond to the treatment when the DNARS score is higher than the predetermined reference value DNARS_g or concluding that the patient will not respond to the treatment when the DNARS score is lower than the predetermined reference value DNARS_R.; $$ \begin{array}{cc}\mathrm{DNARS}=\sum _{i=1}^n\beta i\times \mathrm{Ci}& \left(I\right)\end{array}$$