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CARTILAGE CELLS WITH A HIGH REGENERATIVE POTENTIAL AND LOW IMMUNE RESPONSE FOR USE IN CELLULAR THERAPY
CARTILAGE CELLS WITH A HIGH REGENERATIVE POTENTIAL AND LOW IMMUNE RESPONSE FOR USE IN CELLULAR THERAPY
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机译:具有高再生潜能和低免疫反应的软骨细胞,用于细胞治疗
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摘要
Cell-based therapies for cartilage repair and regeneration selectively using chondrocytes carrying a CD24 surface marker are disclosed. In particular, chondrocytes carrying the CD24 surface marker have a high regenerative potential and low responsiveness to inflammatory cues. Since cartilage injuries as well as chronic cartilage degenerative conditions are often accompanied by a heightened inflammatory environment, cartilage cell populations carrying the CD24 surface marker, which are resistant to the inflammatory environment, provide more efficient cartilage repair. Thus, chondrocytes carrying the CD24 surface marker are useful in cell-based therapies for regenerating or repairing cartilage.
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