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Engineered Invariant Natural Killer T (iNKT) Cells and Methods of Making and Using Thereof
Engineered Invariant Natural Killer T (iNKT) Cells and Methods of Making and Using Thereof
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机译:工程不变自然杀伤T细胞(iNKT)及其制备和使用方法
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摘要
Disclosed are invariant natural killer T (iNKT) cells engineered using hematopoietic stem and progenitor cells (HSPCs) and methods of making and using thereof. Specifically, the engineered cells iNKT are genetically modified to contain at least one exogenous invariant natural killer T cell receptor (iNKT TCR) nucleic acid molecule. Further disclosed are iNKT TCR nucleotide sequences and codon optimized sequences for expression.
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