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USE OF ALGINATE OLIGOMERS IN THE TREATMENT OF CYSTIC FIBROSIS AND OTHER CONDITIONS ASSOCIATED WITH DEFECTIVE CFTR ION CHANNEL FUNCTION
USE OF ALGINATE OLIGOMERS IN THE TREATMENT OF CYSTIC FIBROSIS AND OTHER CONDITIONS ASSOCIATED WITH DEFECTIVE CFTR ION CHANNEL FUNCTION
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机译:藻酸盐低聚物在囊性纤维化及CFTR离子通道功能减退相关的其他疾病中的应用
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摘要
A method is for the treatment of a condition in a human patient arising from or associated with a defective cystic fibrosis transmembrane conductance regulator (CFTR) ion channel and/or abnormal mucus which is attached to underlying epithelium. The method includes administering an alginate oligomer, in which at least 30% of the monomer residues of the alginate oligomer are G residues, to the patient in an amount sufficient to achieve a local concentration of the alginate oligomer of 1 to 6% w/v at at least part of a mucosal surface with a defective CFTR ion channel and/or the abnormal mucus in the patient.
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