首页> 外国专利> POINT-OF-CARE BIOMARKER ASSAY APPARATUS ARRANGED FOR MEASURING A PRESENCE OR CONCENTRATION OF A BIOMARKER IN A SAMPLE

POINT-OF-CARE BIOMARKER ASSAY APPARATUS ARRANGED FOR MEASURING A PRESENCE OR CONCENTRATION OF A BIOMARKER IN A SAMPLE

机译:护理点生物标志物测定装置,用于测量样品中生物标志物的存在或浓度

摘要

Point-of-care biomarker assay apparatus arranged for measuring a presence or concentration of a biomarker in a sample, said biomarker assay apparatus comprising cartridge receiving means arranged for receiving at least one cartridge having multiple chambers designed for receiving a plurality of liquid media comprising said sample, labelled binding reagent, magnetic beads reagent and wash buffer, a sample distribution unit arranged for processing pipetting steps with said chambers, thereby providing a liquid reactant mixture in one or more of said chambers, a magnetic coil assembly arranged for applying a magnetic field to said liquid reactant mixture for separating biomarkers bound to said magnetic beads and said labelled binding reagent, from said reactant mixture, a photo detector or assembly arranged for measuring said presence or concentration of said labelled binding reagent, a control unit arranged for controlling said processing pipetting steps with said chambers, and for controlling said sample distribution unit along said chambers according to a test protocol, wherein said test protocol comprises an order of subsequent processing steps performed in said plurality of chambers to be processed by said sample distribution unit, said processing steps comprising one or more processing pipetting steps by the sample distribution unit and one or more processing incubation steps of the reaction mixture within any of the chambers wherein the control unit being programmed for performing multiple, distinct test protocols.
机译:护理点生物标志物测定装置,其布置为测量样品中生物标志物的存在或浓度,所述生物标志物测定装置包括盒接收装置,其布置为接收至少一个具有多个腔室的盒,所述多个腔室设计用于接收多种液体介质,包括样品,标记的结合试剂,磁珠试剂和洗涤缓冲液,样品分配单元,用于处理带有所述腔室的移液步骤,从而在一个或多个所述腔室中提供液体反应物混合物;电磁线圈组件,用于施加磁场用于从所述反应混合物中分离用于结合到所述磁珠和所述标记的结合试剂的生物标记物的所述液体反应混合物,用于检测所述标记的结合试剂的存在或浓度的光检测器或组件,用于控制所述处理的控制单元用所述腔室进行移液步骤,并进行控制根据测试方案将所述样品分配单元沿所述腔室装入,其中,所述测试方案包括在要由所述样品分配单元处理的所述多个腔室中执行的后续处理步骤的顺序,所述处理步骤包括一个或多个处理移液步骤通过样品分配单元和在任何室内的反应混合物的一个或多个处理温育步骤,其中控制单元被编程为执行多种不同的测试方案。

著录项

  • 公开/公告号US2017246636A1

    专利类型

  • 公开/公告日2017-08-31

    原文格式PDF

  • 申请/专利权人 CITIUSBIO B.V.;

    申请/专利号US201515510318

  • 发明设计人 CHRISTIANUS FRANCISCUS ROSMALEN;

    申请日2015-09-10

  • 分类号B01L7/00;B01L9/00;G01N35/02;C12N15/10;G01N35/04;G01N33/49;C12Q1/68;

  • 国家 US

  • 入库时间 2022-08-21 13:49:43

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