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METHOD FOR TANDEM MASS SPECTROMETRY ANALYSIS IN ION TRAP MASS ANALYZER

机译:离子阱质谱分析仪中串联质谱的分析方法

摘要

This invention is related to a tandem mass spectrometric analysis method in ion trap mass analyzer. Such method comprise three stages as represented by selective isolation, collision induced disassociation and mass scanning of ion. At the collision induced isolation stage, this invention is expected to endow parent ion of certain mass-charge ratio with energy through resonance excitation by changing cycle of radio frequency signals, namely frequency of radio frequency voltage imposed on the ion trap; such high-energy ions produced through resonance excitation are to be disassociated through collision with neutral molecules in the ion trap, which will further generate product ion to realize tandem mass spectrometric analysis. Advantage of this method lies in the fact that it can realize collision induced disassociation by changing scanning cycle at the stage of collision induced disassociation stage through software configuration, which can significantly simplify experimental devices and methods for tandem mass spectrometric analysis.
机译:本发明涉及离子阱质量分析仪中的串联质谱分析方法。这种方法包括三个阶段,以选择性隔离,碰撞诱导的离解和离子的质量扫描为代表。在碰撞诱发的隔离阶段,期望本发明通过改变射频信号的周期,即施加在离子阱上的射频电压的频率,通过共振激发而赋予一定质荷比的母离子能量。这种通过共振激发产生的高能离子将通过与离子阱中的中性分子碰撞而解离,这将进一步产生产物离子,从而实现串联质谱分析。该方法的优点在于,可以通过软件配置改变碰撞诱导解离阶段的扫描周期,实现碰撞诱导解离,从而可以大大简化串联质谱分析的实验装置和方法。

著录项

  • 公开/公告号US2016365231A1

    专利类型

  • 公开/公告日2016-12-15

    原文格式PDF

  • 申请/专利权人 FUDAN UNIVERSITY;

    申请/专利号US201414905912

  • 发明设计人 LIANG WANG;FUXING XU;CHUANFAN DING;

    申请日2014-07-04

  • 分类号H01J49/00;H01J49/42;

  • 国家 US

  • 入库时间 2022-08-21 13:49:30

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