DRUG COCKTAIL ANALYSES USING MICROSCALE VORTEX ASSISTED ELECTROPORATION

摘要

A vortex flow based method for electroporating molecules, e g., sequentially, into cells is provided. The invention provides a method to determine the effect of two or more molecules of interest on cells. The method comprises maintaining a vortex flow in multiple traps having cells of interest; providing a first molecule of interest to the traps and an electric field across the traps for a defined first period of time; providing a second molecule of interest to the traps and an electric field across the traps for a defined second period of time; and determining the combined effect of the first and second molecules on the cells, e.g., whether the combined effect of the first and second molecules on the cells is synergistic, neutral or antagonistic.