Cocktail drug delivery chip for cancer drug screening

摘要

This study introduces a combinatory assay platform that allows high-throughput but low-drug-dosage screening of five anti-cancer drugs as a cocktail for personalized cancer treatment. Photosensitive PEGDA hydrogel was employed for drug dosage definition through drop array formation and selective UV crosslinking process. The finally defined cocktail drugs in hydrogel will be directly released in parallel when combined with cell chips. This device is capable to combine 5 drugs with 1000 folds dynamic range in 30 second with low drug consumption for in-parallel cocktail screening process.