Anti-human Chemokine (C-C motif) Receptor 4 Immunotoxins

摘要

Anti-human chemokine (C—C motif) Receptor 4 immunotoxins and methods of use thereof, e.g., for depleting Tregs as an immunotherapy for the treatment of cancer; for the treatment of cancers associated with CCR4+ tumor cells such as skin homing cutaneous T cell lymphoma, adult T cell leukemia/lymphoma, and acute T-cell lymphoblastic leukemia; and for the depletion of CCCR4+ Th2 cells for the treatment of allergy-related conditions such as asthma.