COMPOSITION FOR INDUCING DIFFERENTIATION OF MULTIPOTENT NEURAL STEM CELLS INTO DOPAMINERGIC NEURONS AND METHOD FOR INDUCING DIFFERENTIATION OF MULTIPOTENT NEURAL STEM CELLS INTO DOPAMINERGIC NEURONS BY USING THE SAME

摘要

Disclosed is a composition for inducing the differentiation of neural stem cells into dopaminergic neurons. The composition includes the compound represented by Formula 1 (“AS703026”) as a MEK 1/2 inhibitor. Also disclosed is a method for inducing the differentiation of neural stem cells into dopaminergic neurons by using the composition. Dopaminergic neurons whose differentiation from neural stem cells is induced by the composition and method can be applied to cell replacement therapies and gene therapies for the treatment of neurodegenerative diseases, such as Parkinson's disease, or can be widely used as materials for the examination of drug effects or numerous studies in the development of new drugs.